Select the favorable conditions required for the formation of oxyhemoglobin at the alveoli.

  1. Low pO2, low pCO2, more H+, higher temperature
  2. High pO2, low pCO2, less H+, lower temperature
  3. Low pO2, high pCO2, more H+, higher temperature
  4. High pO2, high pCO2, less H+, higher temperature

Answer (Detailed Solution Below)

Option 2 : High pO2, low pCO2, less H+, lower temperature
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Detailed Solution

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Concept:

  • Hemoglobin is a respiratory pigment that transports both oxygen and carbon dioxide.
  • About 98 percent of oxygen is transported with the help of hemoglobin.
  • One hemoglobin molecule binds to four oxygen molecules.

Explanation:

  • The partial pressure of oxygen is highest in the alveoli.
  • In alveoli, oxygen binds to hemoglobin to form oxyhemoglobin.
  • Different factors affect the binding of oxygen with hemoglobin.
  • Favorable conditions for the formation of oxyhemoglobin are-high partial pressure of oxygen, low partial pressure of carbon dioxide, low temperature, and less hydrogen ion concentration.
  • Hemoglobin has an affinity for both oxygen and carbon dioxide.
  • The decreased partial pressure of carbon dioxide increases the affinity of binding oxygen with hemoglobin.
  • High pH or less of hydrogen ion causes deprotonation and thus stabilizes the hemoglobin and increases the oxygen binding affinity with hemoglobin.
  • These conditions are present in alveoli and thus promote the formation of oxyhemoglobin.
  • The binding of oxygen with hemoglobin can be explained using an oxygen-dissociation curve.

So, the correct answer is 4.

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