A multiprotem complex that incorporates one strand of a small interfering RNA (SIRNA) or microRNA (miRNA) is called

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  1. RNA-induced silencing complex (RISC)
  2. RNA-induced transcriptional silencing (RITS)
  3. Repeat associated silencing RNAs (ra-SiRNAs)
  4. Short interfering RNAs (SiRNAs)

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Option 1 : RNA-induced silencing complex (RISC)
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The correct answer is RNA-induced silencing complex (RISC)

Explanation:

  • RNA-induced silencing complex (RISC) is a multiprotein complex that plays a crucial role in the RNA interference (RNAi) pathway.
  • RISC incorporates one strand of a small interfering RNA (siRNA) or microRNA (miRNA) and uses this strand to recognize complementary mRNA sequences.
  • Once the target mRNA is recognized, RISC can either degrade the mRNA or inhibit its translation, effectively silencing the gene expression.
  • This mechanism is essential for regulating gene expression and maintaining cellular function.

Other Options:

  • RNA-induced transcriptional silencing (RITS): RITS is another protein complex involved in RNAi, but it primarily functions in the nucleus to mediate transcriptional gene silencing by modifying chromatin structure.
  • Repeat associated silencing RNAs (ra-siRNAs): These are a class of small RNAs involved in the silencing of repetitive elements in the genome, often through mechanisms similar to those employed by RITS.
  • Short interfering RNAs (siRNAs): These are double-stranded RNA molecules, typically 20-25 base pairs in length, that play a role in the RNAi pathway by guiding RISC to complementary mRNA targets for degradation. However, siRNAs themselves are not the complex; they are the molecules that RISC incorporates.
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